A lasered mouse model of retinal degeneration displays progressive outer retinal pathology providing insights into early geographic atrophy
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چکیده
منابع مشابه
Clinical studies on progressive retinal atrophy in 31 dogs
During a 2-year period, 31 cases of a hereditary retinal degeneration in dogs bred in India were found mainly suspected for progressive retinal atrophy (PRA) with typical history of initial nyctalopia followed by hemeralopia. Out of 31 PRA suspected dogs, 8 dogs (26%) were from the age group of 1-5 years, 15 (48%) 6-10 years and the rest (26%) 11-15 years. The most predominant breed was Spitz (...
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Program Number: 5885 Poster Board Number: C0071 Presentation Time: 8:30 AM–10:15 AM Outer Retinal Tubulation as a Predictor of the Growth Rate of Geographic Atrophy in Age-related Macular Degeneration Amirhossein Hariri1, Muneeswar G. Nittala1, Srinivas R. Sadda1, Eric C. Strauss2, Phillip Lai2, Erin Henry2. 1Doheny Eye Institute, Los Angeles, CA; 2Genentech Inc., South San Francisco, CA. Purpo...
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PURPOSE An early-onset retinal degenerative disease has been identified in Persian cats. This study genetically, clinically, and histologically characterized the disease. A breeding colony was established to assist with identification of the causative gene and to provide a resource for vision research. METHODS Cats were produced from testcross breedings. Kittens underwent serial ophthalmic an...
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PURPOSE Diabetic patients who also have retinitis pigmentosa (RP) appear to have fewer and less severe retinal microvascular lesions. Diabetic retinopathy may be linked to increased inner retinal hypoxia, with the possibility that this is exacerbated by oxygen usage during the dark-adaptation response. Therefore, patients with RP with depleted rod photoreceptors may encounter proportionately le...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2019
ISSN: 2045-2322
DOI: 10.1038/s41598-019-43906-z